论文强直性脊柱炎患者血清胶原的表达与临床意义是关于对写作强直性脊柱炎论文范文与课题研究的大学硕士、相关本科毕业论文强直性脊柱炎论文开题报告范文和相关文献综述及职称论文参考文献资料下载有帮助。
[摘 要] 目的 观察胶原在强直性脊柱炎患者血清中的表达. 方法 30例早中期AS患者入组作为AS组,并以30例健康志愿者为对照组.分别检测AS组和对照组受试者外周血清胶原水平.AS组患者评估Bath强直性脊柱炎病情活动指数（BASDAI）、Bath强直性脊柱炎功能指数（BAI）、Bath强直性脊柱炎测量指数（BAI）及檢测血沉、C反应蛋白. 结果 AS组胶原水平较健康对照组显著升高（P<0.05）.AS组患者按CT结果分级,Ⅱ、Ⅲ级AS患者外周血清胶原水平均显著高于对照组（P<0.05）；Ⅰ级AS患者外周血清胶原水平与对照组比较无显著差异（P>0.05）.HLA-B27阳性患者血清胶原水平与HLA-B27阴性患者血清胶原水平比较无显著性差异（P>0.05）.Pearson线性相关分析显示胶原水平和BASDAI,BAI,BAI,ESR及CRP呈显著正相关（P<0.05）. 结论胶原在AS患者外周血清呈高表达,与AS病情有着密切的关联,可以作为AS病情监测的一个重要指标.
[关键词] 强直性脊柱炎；血清学指标；胶原；检测
[中图分类号] R593.23 [文献标识码] A [文章编号] 1673-9701（2018）05-0021-04
[Abstract] Objective To observe the expression of collagen in serum of patients with ankylosing spondylitis. Methods 30 patients with early and middle stage AS were enrolled in AS group, and 30 healthy volunteers were used as control group. The levels of peripheral serum collagen in AS group and control group were detected. The Bath Ankylosing Spondylitis Disease Activity Index（BASDAI）, Bath Ankylosing Spondylitis Function Index（BAI）, Bath Ankylosing Spondylitis Measurement Index（BAI） of patients in the AS group were evaluated. The ESR and C-reactive protein were detected. Results The level of collagen in the AS group was significantly higher than that in the healthy control group （P<0.05）. Patients in the AS group were graded according to the CT results. The levels of peripheral blood collagen in patients with grade Ⅱ and Ⅲ AS were significantly higher than those in the control group（P<0.05）. There was no significant difference in the level of serum collagen in grade Ⅰ AS group and control group（P>0.05）. There was no significant difference in serum collagen level between HLA-B27 positive patients and HLA-B27 negative patients（P>0.05）. Pearson linear correlation analysis showed a significant positive correlation between collagen level and BASDAI, BAI, BAI, ESR and CRP（P<0.05）. Conclusion Collagen is highly expressed in peripheral blood of AS patients, and is closely related to AS condition, which can be used as an important index for monitoring AS condition.
[Key words] Ankylosing spondylitis； Serological indicators； Collagen； Detection
强直性脊柱炎（ankylosing spondylitis, AS）是一种脊柱关节疾病,表现为骶髂关节和脊柱附着点炎症,可引起脊柱纤维化和脊柱强直,甚至导致肌肉、骨骼和肺功能受损[1],因而具有较高的致残率.目前其病因仍不清楚[2].胶原蛋白的过度产生是纤维化的生物标志物[3].本研究通过检测AS患者血清胶原的表达特点,拟探讨血清胶原与AS临床病理参数的关系及其临床应用价值,现报道如下.
1 资料与方法
1.1一般资料
选取2015年5月～2017年3月门诊及住院患者30例作为AS组,其中男26例,女4例；年龄20～50 岁,平均（33.50±10.82）岁；病程4个月～18年,平均（12.68±6.12）年.30例患者人白细胞抗原（HLA）-B27阳性23例,阴性者7例.30例AS患者均符合AS修订纽约分类诊断标准[4],并且骶髂关节炎的CT检查显示Ⅲ级以内改变.骶髂关节炎的CT表现按照纽约修订AS骶髂关节的CT分级标准分为 4 级：Ⅰ级11例,髂骨关节面局部毛糙,硬化,边缘模糊,关节面下骨质局限性条状硬化,关节间隙清晰.Ⅱ级16例, 骶髂关节面毛糙,模糊,条状硬化,关节面下骨质条状、小斑片状硬化,关节间隙存在.Ⅲ级13例,关节面毛糙,边缘不光整,凹凸不平呈锯齿状、虫噬状改变,局部见线条状硬化,关节面下骨质见多个小囊状、虫噬状骨质破坏,其周围见斑片状、条状骨质硬化,关节间隙模糊,宽窄不等.Ⅳ级0例,骶髂关节面模糊不清,局部见线状、条片状密度增高硬化影,关节间隙消失,完全融合、强直.所有AS患者均排除：（1）患者有其他血清阴性脊柱关节疾病,需要用肾上腺皮质激素治疗；（2）怀孕或哺乳期妇女；（3）合并心脏、严重原发性心血管、肝、肾、造血系统疾病及精神疾病.同时以30例健康志愿者作为对照组,其中男23例,女7例； 年龄22～51岁,平均（35.10±11.06）岁.两组的年龄、性别等一般资料比较无统计学差异（P>0.05）.具有可比性.
总结:本文是一篇关于强直性脊柱炎论文范文，可作为相关选题参考,和写作参考文献。
参考文献：
1、 桂西地区脊柱结核患者血清IL27的检测与其临床意义 【摘要】目的检测脊柱结核患者血清白细胞介素27（IL27）的表达水平，以探讨其临床意义。方法选择2016年1～5月收治的30例脊柱结核患者作为观。
2、 运用病友会管理强直性脊柱炎患者的临床疗效评价 【摘 要】目的：探讨以病友会为载体的管理模式对强直性脊柱炎患者干预的效果。方法：将纳入研究的60例强直性脊柱炎患者随机分为研究组和对照组，每组3。
3、 DM患者血清TPO—Ab、TG—Ab水平和血糖相关性 [摘要] 目的 探讨糖尿病患者血清TPO-Ab、TG-Ab水平与血糖含量的关系。 方法 所有研究对象于早晨空腹采集静脉血，对所采集的血液标本采用。
4、 冠心病患者血清BNP、VEGF、hs—CRP检测价值评估 [摘要] 目的 分析冠心病（CHD）患者血清BNP（B 型鈉尿肽）、VEGF（血管内皮生长因子）、hs-CRP（高敏 C 反应蛋白）检测的价值情。
5、 青春和胶原蛋白 忘了是哪位大作家说过：青春的躯体从外面看起来在发光，待在里面的时候倒觉得空空荡荡。是什么令青春发光？这是物理学家、生物学家和文学家都在追问的问题。